U.S. health officials say they have reports of at least 29 people developing severe allergic reactions to the coronavirus vaccines, but they stress that the risk for most people is low.

The CDC on Wednesday released its latest count of side effects suffered by more than 5.3 million people who have been vaccinated. The 29 had suffered anaphylaxis, a life-threatening allergic reaction that can be controlled through an epinephrine injection.

That’s a rate of about 5.5 cases per million people, which is roughly four times higher than the rate seen in a study of people who got flu shots.

The CDC also published a more detailed study of the first 1.9 million Americans vaccinated as of Dec. 23. Among that group, 21 of suffered the severe allergic reaction. CDC had full data on 20 of the cases, and none of them died, agency officials said. Nineteen got epinephrine and four were hospitalized.

Anyone who has a severe reaction to a first dose should not get a second dose of the vaccine, the CDC says.

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